Molecular Cloning of the Interleukin-1β Converting Enzyme
- 3 April 1992
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 256 (5053) , 97-100
- https://doi.org/10.1126/science.1373520
Abstract
Interleukin-1β (IL-1β) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1β to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.Keywords
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