A Molecular Model of Action Potentials
Open Access
- 1 July 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (7) , 2858-2862
- https://doi.org/10.1073/pnas.71.7.2858
Abstract
A QUANTITATIVELY CONSISTENT MODEL OF NERVE ACTIVITY IS GIVEN IN TERMS OF TWO MAIN BIOCHEMICAL CYCLES NARROWLY INTERLOCKED: an acetylcholine cycle and a calcium cycle. The activity of both cycles is controlled among other things by the electric field and various allosteric effectors. As shown by digital simulations our model accounts for the basic properties of an action potential as described by the electrophysiologists. Thus the shape, time course, and behavior under voltage clamping conditions of both sodium and potassium permeability variations are adequately reproduced.Keywords
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