Tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovorin
- 1 August 1989
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 38 (16) , 2677-2684
- https://doi.org/10.1016/0006-2952(89)90554-6
Abstract
No abstract availableThis publication has 35 references indexed in Scilit:
- Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolateAntimicrobial Agents and Chemotherapy, 1988
- Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infectionAntimicrobial Agents and Chemotherapy, 1987
- Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.The Journal of Experimental Medicine, 1987
- Pneumocystis carinii Pneumonia: A Comparison Between Patients with the Acquired Immunodeficiency Syndrome and Patients with Other ImmunodeficienciesAnnals of Internal Medicine, 1984
- Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediaminesJournal of Medicinal Chemistry, 1983
- Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidineJournal of Medicinal Chemistry, 1980
- Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblastsBiochemical Pharmacology, 1980
- Effect of the substituent at C-6 on the biological activity of 2,4-diamino-5-(1-adamantyl) pyrimidinesJournal of Medicinal Chemistry, 1973
- 5-Benzyl-2,4-diaminopyrimidines as Antibacterial Agents. I. Synthesis and Antibacterial Activity in vitroJournal of Medicinal Chemistry, 1962
- Clinical Effects of the Dichloro and Monochlorophenyl Analogues of Diamino Pyrimidine: Antagonists of Folic Acid12Journal of Clinical Investigation, 1954