Central Effect of Dibutyryl Cyclic AMP on the Temperature in the Conscious Rabbit

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Abstract
In the rabbit, intracerebroventricular administration of dibutyryl cyclic[c]AMP (DBC) produces fever which is selectively antagonized by phenoxybenzamine. This indicates the involvement of central .alpha.-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine (6-OH-DA) supports the viewpoint that DBC-induced fever is dependent on the presence of noradrenaline (NA, norepinephrine) in the CNS. The accentuation of NA hyperthermia by theophylline suggests that NA fever may be mediated by cAMP. It is unlikely that DBC-induced hyperthermia in the rabbit is mediated via prostaglandins since indomethacin does not inhibit this response to DBC.