A Comparison of Rosoxacin with Ampicillin and Probenecid in the Treatment of Uncomplicated Gonorrhea

Publisher Website
Google Scholar
Abstract
Rosoxacin, a .beta.-lactamase-resistant, pyridyl quinolone derivative with in vitro activity against Neisseria gonorrhoeae, was compared to an oral regimen of ampicillin plus probenecid for the treatment of uncomplicated gonococcal infection. Patients (57) were evaluated for the effectiveness of the 2 antibiotics. Of 31 patients receiving rosoxacin, 30 (97%) were cured of their infection as were 25 (96%) of 26 patients who received the oral regimen of ampicillin plus probenecid. Both drug regimens were associated with a significant number of side effects. Of the ampicillin-treated group, 29% had diarrhea and/or abdominal cramping. Of the rosoxacin-treated patients, 52% had reactions classified as CNS effects; these included headaches, dizziness, euphoria and drowsiness.

This publication has 1 reference indexed in Scilit: