Intrarenal Urinary Extravasation With Formation of Venous Polyps Containing Tamm-horsfall Protein

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Abstract
Collections of periodic acid-Schiff-positive material were found in intrarenal veins and in renal interstitium in certain cases of hydronephrosis and unexplained unilateral hematuria [in humans]. Using a fluorescent antibody to Tamm-Horsfall protein, a protein secreted by the ascending limbs and distal convoluted tubules, the venous and interstitial masses represent urinary filtrate, which probably enters the kidney parenchyma through forniceal or tubular ruptures, was demonstrated.