A seven days course of eflornithine for relapsing Trypanosoma brucei gambiense sleeping sickness
- 1 March 1997
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 91 (2) , 212-213
- https://doi.org/10.1016/s0035-9203(97)90228-5
Abstract
Forty-seven patients with a relapse following a first treatment of Trypanosoma brucei gambiense trypanosomiasis were treated with a 7 d course of intravenous eflornithine (100 mg/kg every 6 h) and followed for 2 years. Four patients died after treatment, 2 of them possibly due to trypanosomiasis. One patient was completely lost to follow-up, 36 were followed for at least one year, and 25 have completed the 2 years' follow-up. Only one patient, a 5 years old child, subsequently relapsed. Considering this child and 2 of the fatalities as treatment failures, the rate of failure was 6·5%. A 7 d course of intravenous eflornithine is an adequate treatment for cases of Gambian trypanosomiasis relapsing after treatment with another drug.Keywords
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