Effect of Interval between Inoculation of Live Smallpox and Yellow-Fever Vaccines on Antigenicity in Man

Open Access
Publisher Website
Google Scholar
Abstract
In the first part of this study, volunteers were initially given smallpox vaccine; yellow-fever vaccine was given to groups of these volunteers simultaneously, and 3, 7, 14, and 28 days later. Part two was essentially the same, except that yellow-fever vaccine was administered initially, and the time of smallpox vaccination varied as indicated above. The results showed that the reactogenicity and antigenicity of live smallpox and yellow-fever vaccines were unaffected by the interval between inoculations. The advantages of administering live-virus vaccines, either simultaneously or at different times, were evaluated. It was suggested that the recommendations on immunization with smallpox and yellow-fever vaccines be modified in light of the findings of this study.

This publication has 0 references indexed in Scilit: