Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization
- 16 February 1998
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 37 (3) , 347-349
- https://doi.org/10.1002/(sici)1521-3773(19980216)37:3<347::aid-anie347>3.0.co;2-5
Abstract
Extremely fast cyclization of the linear polypeptide precursor 1 takes place to form 2. The reaction appears to be assisted by the native fold of 1, which positions the reactive ends in close proximity. The circular topology has no influence on the folding or function of 2.This publication has 0 references indexed in Scilit: