Moving Forward: Mechanisms of Chemoattractant Gradient Sensing
Open Access
- 1 October 2004
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 19 (5) , 300-308
- https://doi.org/10.1152/physiol.00017.2004
Abstract
Cells use an internal compass to sense the direction of chemoattractant gradients. This is used to bias pseudopod extension at the front of the cell and to orient cell polarization. Recent studies have highlighted the important roles played by phosphoinositide-3,4,5-triphosphate and small G proteins, but many questions remain.Keywords
This publication has 58 references indexed in Scilit:
- A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxisBiochemical and Biophysical Research Communications, 2004
- Novel Mechanism of PTEN Regulation by Its Phosphatidylinositol 4,5-Bisphosphate Binding Motif Is Critical for ChemotaxisJournal of Biological Chemistry, 2004
- Making all the right moves: chemotaxis in neutrophils and DictyosteliumCurrent Opinion in Cell Biology, 2004
- Inositol Pyrophosphates Mediate Chemotaxis in Dictyostelium via Pleckstrin Homology Domain-PtdIns(3,4,5)P3 InteractionsCell, 2003
- PIR121 Regulates Pseudopod Dynamics and SCAR Activity in DictyosteliumCurrent Biology, 2003
- Myosin II contributes to the posterior contraction and the anterior extension during the retraction phase in migratingDictyosteliumcellsJournal of Cell Science, 2003
- Polarization of Myosin II Heavy Chain-Protein Kinase C in Chemotaxing Dictyostelium CellsPublished by Elsevier ,2002
- Activation of Phosphoinositide 3-Kinase γ by RasCurrent Biology, 2002
- Tumor Suppressor PTEN Mediates Sensing of Chemoattractant GradientsCell, 2002
- Integration of Signaling Networks that Regulate Dictyostelium DifferentiationAnnual Review of Cell and Developmental Biology, 1999