PROPHYLAXIS OF VENOUS THROMBOSIS AFTER MAJOR THORACIC SURGERY

Publisher Website
Google Scholar
Abstract
The high incidence (50-60%) of deep venous thrombosis of the legs (DVT) after major thoracic surgery is reduced only by about half with routine low-dose heparin prophylaxis. The efficacy of a higher dose of heparin (7500 U twice daily) was compared with the commonly used dose of 5000 U twice daily in preventing scan-detected DVT in 100 consecutive patients having thoracotomy for carcinoma of the lung or esophagus. After the higher dose of heparin, postoperative DVT was not significantly less frequent (22 compared with 33% for total DVT) but was significantly less extensive (8 and 14%, respectively, for bilateral calf DVT, and 0 and 4% for popliteal DVT). Despite prophylaxis, DVT was especially common after esophagogastrectomy (41% total DVT, 30% extensive DVT). No excessive postoperative bleeding was noted in either group. Evidently, an increased dose of heparin safely offers increased prophylaxis against DVT in patients undergoing major thoracic surgery for cancer.