The eosinophil ribonucleases
- 1 August 1998
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 54 (8) , 795-803
- https://doi.org/10.1007/s000180050208
Abstract
The eosinophil ribonucleases, eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are two closely related proteins with intriguing functional and evolutionary properties. While both EDN and ECP maintain the structural and catalytic residues typical of the RNase A superfamily, the role of ribonuclease activity in the physiologic function of these proteins remains unclear. The biochemistry and physiology of EDN, ECP and the recently discovered ribonuclease k6 (RNase 6) will be reviewed in this chapter.Keywords
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