Decreased Neutrophil Cyclic AMP Response to Isoprenaline Stimulation in the Elderly
- 31 July 1983
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 65 (2) , 155-157
- https://doi.org/10.1042/cs0650155
Abstract
1. Neutrophils from drug-free elderly subjects produced approximately 50% less cyclic AMP in response to isoprenaline than did neutrophils from young subjects. A significant difference in basal cyclic AMP levels was also evident (elderly 2.8 ± 0.37; young 4.9 ± 0.36 pmol of cAMP/107 cells; P < 0.05). 2. With a range of anti-neutrophil monoclonal antibodies no evidence of age-related neutrophil population heterogeneity was found. 3. These findings indicate that the age-related decline in β-adrenoceptor responsiveness is not due to changes in the neutrophil population. 4. The present results support the hypothesis that there is a generalized decline in β-adrenoceptor-mediated responsiveness in the elderly.Keywords
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