Endogenous Gonadotropin Requirements for Follicular Growth and Maintenance in Immature Rats Pretreated with PMS1

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Abstract
Anti-PMS serum (APS) was used to explore the role of endogenous gonadotropins in follicular development and maintenance in immature rats pretreated with PMS. HCG was used as an ovulating hormone to test the ability of follicles to ovulate. The hormones and antiserum were administered intravenously. When PMS was given at 0800 hr on day 26, ovulation occurred in 92% of the rats on the morning of day 29. No ovulation occurred when APS was administered simultaneously with PMS. By concurrent administration of hCG with APS 24, 30, or 36 hr after PMS, ovulation was induced in 10, 46, or 64% of the animals on the morning of day 28. When APS was given 24, 30, or 36 hr after PMS, followed by hCG 55 hr after PMS, ovulation occurred in 0, 46, or 100% of the animals on the morning of day 29. When the APStreated rats received no hCG, ovulation occurred only in the group given APS 36 hr after PMS with no significant difference from that of PMS treated controls (82% vs 92% in control). In hypophysectomized immature rats, circulating gonadotropin is required to maintain follicular ability to ovulate until at least 3 hr before ovulating hormone administration (Sasamoto and Kennan, 1972). It is concluded, therefore, that priming PMS is necessary for an initial stimulation of follicular development during the first 36 hr following the injection. Thereafter, endogenous gonadotropins are responsible for further development and maintenance of the follicles in an ovulable state. (Endocrinology93: 292, 1973)

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