Hypothermic hemoconcentration

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Abstract
The basis of hemoconcentration during hypothermia was studied in some 35 acute experiments on anesthetized dogs. All dogs were made progressively hypothermic by packing in ice and rectal temperature was reduced from normothermic control of 38 C to 27 C. In series 1, 10 dogs showed an increase in hematocrit of 28.6 [plus or minus] 3.7%. Total protein determined by refractometry and by the biuret method showed respective increases of 9.4 [plus or minus] 1.6% and 14.1 [plus or minus] 1.4%. In series 2, 2 dogs were tested for 4 hr under normothermic conditions. Little change in hematocrit and total protein was found. In series 3, 7 dogs were acutely splenectomized and treated as in series 1. The increase in hematocrit was 7.8 [plus or minus] 1.5% while total protein increased 5.51 2.1% and 4.7 i 1.0%. In series 4, 4 dogs chronically splenectomized and then tested as in series 1 showed results similar to series 3. A major cause of hemoconcentration in hypothermic dogs may be due to splenic contraction.

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