Sirenomelia and Monomelia with Renal Agenesis and Amnion Nodosum

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Abstract
Two cases of sirenomelia and two of monomelia have been described in view of additional features not mentioned in previous reports. The Potter facies, large spade-like hands and pulmonary hypoplasia were present in all four cases. Examination of the placentae in 3 cases revealed the lesion of amnion nodosum a finding indicative of oligohydramnios, which was in fact noted clinically in 2 instances. We conclude that severe urinary tract dysplasia, such as renal agenesis or complete urethral atresia, and its associated fetal and placental changes are a constant finding in sirenomelia and monomelia.

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