Platelet-derived growth factors: A family of isoforms that bind to two disticnt receptors
- 1 March 1989
- journal article
- review article
- Published by Oxford University Press (OUP) in British Medical Bulletin
- Vol. 45 (2) , 453-464
- https://doi.org/10.1093/oxfordjournals.bmb.a072334
Abstract
Platelet-derived growth factor (PDGF) is a mitogen for connective tissue cells and accurs as disulphide-bonded homodimers or heterodimers of related polypeptide chains. Recent date indicate that the isoforms have different functional activities due to the fact that they bind with different affinities to two distinct receptor types. The frequent expression of PDGF and PDGF receptors in normal as well as transformed cells, suggests roles for PDGF in autocrine and paracrine stimulation of cell growth in vivoKeywords
This publication has 0 references indexed in Scilit: