Catecholamines and Neurologic Diseases

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Abstract
(Second of Two Parts)Evidence Relating Brain Catecholamines to Specific Neurologic DiseasesParkinson's DiseaseThe role of catecholamines in Parkinson's disease has been examined more extensively than in any other neurologic disorder. Since several excellent reviews have previously been published on this relation,9, 58 59 60 the following discussion provides only a brief outline of the varieties of evidence implicating catecholamines in the pathogenesis of Parkinson's disease. Striatal dopamine content in the postencephalitic, senile-arteriosclerotic, and idiopathic forms of Parkinson's disease is decreased in approximate proportion to the cell loss in the pars compacta of the substantia nigra, and to the akinesia observed premortem. . . .