Multiple Alignment of DNA Sequences with MAFFT
Top Cited Papers
- 28 February 2009
- book chapter
- Published by Springer Nature
- Vol. 537, 39-64
- https://doi.org/10.1007/978-1-59745-251-9_3
Abstract
Multiple alignment of DNA sequences is an important step in various molecular biological analyses. As a large amount of sequence data is becoming available through genome and other large-scale sequencing projects, scalability, as well as accuracy, is currently required for a multiple sequence alignment (MSA) program. In this chapter, we outline the algorithms of an MSA program MAFFT and provide practical advice, focusing on several typical situations a biologist sometimes faces. For genome alignment, which is beyond the scope of MAFFT, we introduce two tools: TBA and MAUVE.Keywords
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