Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats
- 1 January 1994
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 11 (8) , 1174-1179
- https://doi.org/10.1023/a:1018997101542
Abstract
The relative effectiveness of two β-cyclodextrin derivatives, i.e., dimethyl-β-cyclodextrin (DMβCD) and hydroxypropyl-β-cyclodextrin (HPβCD), in enhancing enteral absorption of insulin was evaluated...Keywords
This publication has 13 references indexed in Scilit:
- A Simple Method of Correlating Pharmacodynamic Equivalence with Absolute Bioavailability Following Noninvasive Delivery of InsulinPharmaceutical Research, 1994
- Nasal Insulin Delivery with Dimethyl-β-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid FormulationsPharmaceutical Research, 1993
- Abaorption Enhancement to Polypeptide Drugs by Cyclodextrins. Part II. Enhancing Effect of Cyclodextrins on Nasal Absorption of Insulin and Its Duration in Rabbits.CHEMICAL & PHARMACEUTICAL BULLETIN, 1992
- Dissociation of Insulin Oligomers by Bile Salt Micelles and Its Effect on α-Chymotrypsin-Mediated Proteolytic DegradationPharmaceutical Research, 1992
- Cyclodextrins as Nasal Absorption Promoters of Insulin: Mechanistic EvaluationsPharmaceutical Research, 1992
- Pharmacodynamics of Insulin Following Intravenous and Enteral Administrations of Porcine-Zinc Insulin to RatsPharmaceutical Research, 1992
- Absorption Enhancing Effect of Cyclodextrins on Intranasally Administered Insulin in RatsPharmaceutical Research, 1991
- Degradation of Insulin by Trypsin and Alpha-ChymotrypsinPharmaceutical Research, 1991
- COMPARISON OF NASAL, RECTAL, BUCCAL, SUBLINGUAL AND INTRAMUSCULAR INSULIN EFFICACY AND THE EFFECTS OF A BILE-SALT ABSORPTION PROMOTER1988
- Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeabilityBrain Research Bulletin, 1985