SOME COMPARATIVE EFFECTS OF TESTOSTERONE DERIVATIVES IN THE MONKEY1

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Abstract
Comparison of the increase in wt. of the accessory genitalia in immature castrate macaques was made following subcut. implantations of testosterone 17-propionate, testosterone 3,17-propionate, and testosterone 17-methyl. A greater relative increase in the wt. of either lobe of the prostate or the seminal vesicles, or both as a whole, occurred following implantation of testosterone 3,17-propionate. This was calculated in mgs. of accessory genitalia per mg. of absorbed hormone. The effectiveness of testosterone 17-propionate was moderately more effective than that of pellets of testosterone 17-methyl; but when these were compared with testosterone 3,17-dipropionate, the latter showed a striking increase in effectiveness. Pellets of pure testosterone were the least effective of these 3 substi-tution products. The avg. daily absorption from a pellet of testosterone 3,17-propionate (di-propionate) was .3 mg. and about 1/5th that of testosterone 17-propionate (Perandren) and 1/6th as great as either testosterone 17-methyl or testosterone. The esters of testosterone, especially the di-esters in the form of subcut. crystals, seem to be more efficient than those of testosterone or the inj. of testosterone pro-pionate in oil.

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