Detailed Characterization of the Lipid Composition of Detergent-Resistant Membranes from Photoreceptor Rod Outer Segment Membranes
- 1 April 2005
- journal article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 46 (4) , 1147-1154
- https://doi.org/10.1167/iovs.04-1207
Abstract
Purpose. In recent years, detergent-resistant membranes (DRMs) have been isolated in in vitro models of lipid rafts, from photoreceptor outer segments (ROS), and the localization of a specific complement of photoreceptor proteins has been demonstrated. However, surprisingly little is known about the lipid composition of these important membrane domains. The present study provides the first characterization of phospholipids and fatty acids from ROS-derived DRMs.Keywords
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