DNA strand breakage in freshwater mussels (Anodonta grandis) exposed to lead in the laboratory and field
- 1 May 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Environmental Toxicology and Chemistry
- Vol. 15 (5) , 802-808
- https://doi.org/10.1002/etc.5620150528
Abstract
The sensitivity of a freshwater mussel, Anodonta grandis, to DNA damage following lead (Pb) exposure was tested in laboratory and field experiments. Laboratory exposures were conducted for 4 weeks at the following Pb concentrations: 0 (controls), 50, 500, and 5000 μg/L. Mussels were also collected from a strip‐mine pond contaminated with trace amounts of lead, cadmium (Cd), and zinc (Zn). Significant DNA strand breakage was observed in foot tissue from mussels exposed in the laboratory to the lowest Pb concentration (50 μg/L). No evidence of strand breakage was observed in any of the analyzed tissues from the mussels exposed to higher Pb concentrations (500 and 5000 μg/L) or from the chronically exposed mussels collected from the strip‐mine pond. These data suggest a threshold effect for DNA damage and repair resulting from low‐level Pb exposure, whereby repair of DNA strand breaks may occur only if a certain body burden or exposure duration has been achieved.Keywords
This publication has 34 references indexed in Scilit:
- The molecular basis of nucleotide excision repair syndromesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994
- Bioaccumulation of PCB congeners by blue mussels (Mytilus edulis) deployed in New Bedford Harbor, MassachusettsEnvironmental Toxicology and Chemistry, 1993
- Comparison of two freshwater turtle species as monitors of radionuclide and chemical contamination: DNA Damage and residue analysisEnvironmental Toxicology and Chemistry, 1993
- Sequential expression of biomarkers in Bluegill Sunfish exposed to contaminated sedimentEcotoxicology, 1992
- Biological and physical factors affecting the body burden of organic contaminants in freshwater musselsArchives of Environmental Contamination and Toxicology, 1990
- Effects of metals on chromosomes of higher organismsEnvironmental Mutagenesis, 1987
- An in vivo sister-chromatid exchange assay in the larvae of the mussel Mytilus edulis: response to 3 mutagensMutation Research Letters, 1982
- Some experiments on the action of lead acetate on human leukocytes in vitroMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Distribution of Iron, Magnesium, Copper, Zinc, and Silver in Oysters Along the Georgia CoastJournal of the Fisheries Research Board of Canada, 1972
- Chromosomenanalysen in zellkulturen des chinesischen hamsters nach applikation von bleiacetatMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972