Synthesis of a monocyclic β-lactam stereospecifically labelled at C-4
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2811-2814
- https://doi.org/10.1039/p19830002811
Abstract
In connection with biosynthetic studies, the β-lactams (5; 4-HR=2H) and (5; 3-H = 4-HS=2H) have been synthesized. The 1H and 2H n.m.r. spectra of these compounds confirm the assignment of the stereochemistry to the two hydrogens at C-4 of monocyclic β-lactams such as nocardicin A. Samples of the amino-acid L-asparagine stereospecifically labelled at C-3 have been made in the course of this work.This publication has 1 reference indexed in Scilit:
- The Stereochemistry of beta-Lactam Formation in Penicillin BiosynthesisEuropean Journal of Biochemistry, 1977