Renal clearance and plasma protein binding of oxytetracycline in man
- 1 January 1960
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 15 (1) , 106-108
- https://doi.org/10.1152/jappl.1960.15.1.106
Abstract
The clearance of oxytetracycline was measured in eight children, four of whom also received glucosamine. The average clearance of oxytetracycline was 163.7 ml/min./1.73 m2 in the eight experiments and the average clearance of inulin was 115.8 ml/min/1.73 m2. About two-thirds of the oxytetracycline appearing in the urine was filtered at the glomeruli. One-third was secreted by the tubules. About three-fourths of the oxytetracycline in human plasma was found to be dialyzable and one-fourth bound to protein. Glucosamine (40 mg/kg) administered for 24 hours did not significantly modify the renal tubular secretion of oxytetracycline. Note: (With Technical Assistance by S. Graziano and R. Kanter) Submitted on April 22, 1959Keywords
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