DEFECTIVE NATURAL-KILLER CYTO-TOXICITY AND POLYMORPHONUCLEAR LEUKOCYTE ANTIBODY-DEPENDENT CELLULAR CYTO-TOXICITY IN PATIENTS WITH LFA-1/OKM-1 DEFICIENCY

  • 1 January 1984
    • journal article
    • research article
    • Vol. 133  (6) , 2972-2978
Abstract
Four children with an immunodeficiency involving the absence of leukocyte membrane glycoproteins reacting with anti-LFA-1 and OKM-1 monoclonal antibodies were unable to mediate adherence-dependent leukocyte functions. Even with normal Fc receptor function, their PMN-ADCC [polymorphonuclear leukocyte-antibody dependent cellular cytotoxicity] and MC-NKC [mononuclear cell-natural killer cytotoxicity] were markedly deficient. Single cell analysis demonstrated deficient antibody-mediated PMN-target cell adherence. Monoclonal antibodies against LFA-1 and OKM-1 reproduced this immunodeficiency in leukocytes from normal adults. LFA-1/OKM-1 mediates a PMN-target cell adhesive step.