One Step Preparation of 1,4-Diketones from Methyl Ketones and α-Bromomethyl Ketones in the Presence of ZnCl2 · t-BuOH · Et2NR as a Condensation Agent
- 31 December 2000
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2000 (09) , 1259-1262
- https://doi.org/10.1055/s-2000-6418
Abstract
1,4-Diketones have been prepared in one step from methyl ketones and α-bromomethyl ketones under the action of ZnCl2 · t-BuOH · Et2NR as a condensation agent with moderate to high yields. The mechanistic pathway of the reaction is proposed to go through aldol condensation of ketones followed by 1,3-dehydrobromination of aldol products and cleavage of activated cyclopropyl intermediates.Keywords
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