2',2'-Difluorodeoxycytidine Metabolism and Mechanism of Action In Human Leukemia Cells
- 1 January 1989
- journal article
- plenary lectures
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (5) , 775-785
- https://doi.org/10.1080/07328318908054215
Abstract
The toxicity of 2′,2′-difluorodeoxycytidine is due to the inhibition of DNA synthesis by a nucleotide metabolite by either direct inhibition of the process of DNA synthesis and/or to inhibition of ribonucleotide reductase.Keywords
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