Transcription of biliary glycoprotein I gene in malignant and non‐malignant human liver tissues

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Abstract
Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least II related genes. The transcription of BGP I gene was analysed in malignant and non‐malignant human liver tissues with a 396‐bp 3′‐untranslated region probe from a cDNA clone 4‐13 which was newly isolated from an adult human colon cDNA library. Among 21 tissue samples from 14 patients with hepatocellular carcinoma, 16 samples were clearly shown to express a single 3.9‐kb message. This message was also found in the hepatoma cell line HuH‐7. When the malignant tissues were compared to the non‐malignant ones for the intensity of the band, no significant difference was observed. mRNAs of CEA and non‐specific cross‐reacting antigen (NCA) were not detected in 5 samples which were shown to have the message of the BGP I gene. These data suggest that the human hepatocyte and its malignant transformant produce BGP I, and that this could correspond to the cross‐reacting antigen previously detected in the liver.

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