Abstract
In an attempt to discover a small laboratory animal which will act as a suitable host for Brugia malayi or B. pahangi, guinea-pigs, rabbits and white mice were inoculated with infective larvae. No evidence of development of either parasite was found in any of the animals used. Attempts were made to breakdown the natural resistance of these animals to infection with B. malayi or B. pahangi by removal of the spleen, by irradiation and by treatment with 6-mer-captopurine. These attempts were unsuccessful.