Evidence for a two-stage model of microbial infection
- 1 June 1968
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 66 (2) , 273-280
- https://doi.org/10.1017/s0022172400041139
Abstract
SUMMARY: Colony counts on mice given the same number ofSalmonellaalways differ considerably. However, the standard error of the mean log count does not increase after the first 1·5 hr. of infection until the 8th or 10th day. These infections therefore appear to pass through an initial stage lasting a few hours, in which a varying proportion of the inoculum is killed, followed by a prolonged second stage in which the scatter in individual colony counts remains constant.Keywords
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