Development and characterization of a new murine renal tumor model
- 1 November 1983
- journal article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 11 (3)
- https://doi.org/10.1007/bf00254201
Abstract
A murine renal cell carcinoma model, the RC tumor, was pharmacologically and histologically characterized and was used for the evaluation of 20 chemotherapeutic agents. This model, when implanted IP or SC showed reproducible behavior and was found to be very sensitive to many drugs with different mechanisms of action, and particularly to alkylating agents. The IP-implanted tumor was sensitive to some clinically active drugs which were reported inactive against L1210 or P388 murine leukemias.Keywords
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