Cell cycle in mouse development
Open Access
- 18 April 2005
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 24 (17) , 2877-2898
- https://doi.org/10.1038/sj.onc.1208608
Abstract
Mice likely represent the most-studied mammalian organism, except for humans. Genetic engineering in embryonic stem cells has allowed derivation of mouse strains lacking particular cell cycle proteins. Analyses of these mutant mice, and cells derived from them, facilitated the studies of the functions of cell cycle apparatus at the organismal and cellular levels. In this review, we give some background about the cell cycle progression during mouse development. We next discuss some insights about in vivo functions of the cell cycle proteins, gleaned from mouse knockout experiments. Our text is meant to provide examples of the recent experiments, rather than to supply an extensive and complete list.Keywords
This publication has 270 references indexed in Scilit:
- Hitting their targets: an emerging picture of E2F and cell cycle controlCurrent Opinion in Genetics & Development, 2004
- Molecular Cloning and Characterization of the Mouse E2F6 GeneBiochemical and Biophysical Research Communications, 2001
- Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer modelOncogene, 2000
- Thein VivoExpression Pattern of Mouse Nek2, a NIMA-Related Kinase, Indicates a Role in both Mitosis and MeiosisExperimental Cell Research, 1997
- Dynamic Organization of DNA Replication in One-Cell Mouse Embryos: Relationship to Transcriptional ActivationExperimental Cell Research, 1997
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature, 1993
- Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisNature, 1992
- Effects of an Rb mutation in the mouseNature, 1992
- Relationship between growth and meiotic maturation of the mouse oocyteDevelopmental Biology, 1976
- Fertilization of the mouse oocyte: Sequence and timing of nuclear progression to the two‐cell stageJournal of Experimental Zoology, 1972