An Examination of the Decomposition of Dextrose Solution During Sterilisation
- 1 December 1960
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 12 (Supplement) , 191T-196T
- https://doi.org/10.1111/j.2042-7158.1960.tb10475.x
Abstract
A method is described for assessing the degree of decomposition of dextrose in solutions by measuring absorptiometrically the blue colour produced by a reaction with Folin-Ciocalteu reagent. The amount of decomposition depends on the duration and temperature of the sterilisation process, the concentration of dextrose and the presence of added substances. It is minimal at about pH 3. A product other than 5-hydroxymethylfurfural is formed. Two breakdown products of dextrose, gluconic acid and 5-hydroxymethyfurfural, also progressively alter in composition when their solutions are autoclaved for increasing periods either separately or as a mixture.Keywords
This publication has 3 references indexed in Scilit:
- A Study of the Decomposition of Glucose Solutions**research laboratories of Purdue University School of Pharmacy, Lafayette, Ind.Journal of the American Pharmaceutical Association (Scientific ed.), 1958
- The Role of 5-(Hydroxymethyl)-furfural in the Discoloration of Sugar SolutionsJournal of the American Chemical Society, 1948
- Formation of 5-Hydroxymethylfurfural from D-Glucose in Aqueous Solution1Journal of the American Chemical Society, 1945