Hepatocytes Immobilised by Microencapsulation in Artificial Cells: Effects on Hyperbilirubihemia in Gunn Rats

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Abstract
The possibility of using hepatocytes encapsulated in a calciumalginate-polylysine matrix to lower bilirubin levels in hyperbilirubinemia was investigated. The animal model was the Gunn rat. The microencapsulated hepatocytes were injected intraperitoneally. 15×106 microencapsulated hepatocytes from Wistar rats, lowered the bilirubin from 14 mg/100 ml to 6 mg/100 ml after 20 days. The bilirubin is still depressed after 90 days. After encapsulation, Sprague-Dawley hepatocytes were as effective as free hepatocytes in lowering bilirubin levels in Gunn rats. After 68 days, the free Sprague-Dawley hepatocytes were not rejected.