THE TREATMENT OF THYROTOXICOSIS WITH AMINOTHIAZOLE—RESULTS IN TWENTY-THREE CASES

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Abstract
23 patients with thyrotoxicosis were treated with aminothiazole. The initial dosage was 0.6 g. given in 3 divided doses. The avg. daily dose required by medical patients who tolerated the drug was 0.05 to 0.2 g. The drug had to be discontinued in 7 of the 14 patients treated medically and in 5 of the 9 surgical cases because of toxic reactions which included: (1) fever with malaise, (2) nausea and vomiting, (3) skin eruptions, (4) pruritis without skin lesions, (5) arthralgias of mild and severe degree, (6) jaundice with evidence of liver damage, (7) generalized lympha-denopathy. A protocol of the case of a patient with a severe reaction is given. On the basis of this experience, the use of aminothiazole in thyrotoxicosis does not appear to be justified because of its toxicity and relatively low antithyroid effect.