Irreversible Translation Arrest in the Reperfused Brain
Open Access
- 16 August 2006
- journal article
- review article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 27 (5) , 875-893
- https://doi.org/10.1038/sj.jcbfm.9600388
Abstract
Irreversible translation arrest occurs in reperfused neurons that will die by delayed neuronal death. It is now recognized that suppression of protein synthesis is a general response of eukaryotic ...Keywords
This publication has 148 references indexed in Scilit:
- Irreversible aggregation of protein synthesis machinery after focal brain ischemiaJournal of Neurochemistry, 2006
- Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcriptsBiochemical and Biophysical Research Communications, 2004
- Shutdown of Translation: Lethal or Protective? Unfolded Protein Response versus ApoptosisJournal of Cerebral Blood Flow & Metabolism, 2003
- An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative StressPublished by Elsevier ,2003
- IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNANature, 2002
- Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca2+-ATPase: relationship between global protein synthesis and expression and translation of individual genesBiochemical Journal, 2001
- Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damageMedical Hypotheses, 1996
- Impairment of protein ubiquitination may cause delayed neuronal deathNeuroscience Letters, 1989
- Molecular Mechanisms of Ischemic Damage of Spinal CordGerontology, 1987
- Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology, 1982