Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. IX. Synthesis of 1, 1, 5-Trimethyl-2-ethyl-and 1, 1, 2, 4, 5-Pentamethyl-3-diphenylmethylenepyrrolidinium Iodide as Potential Anticholinergic Agents
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 96 (8) , 952-956
- https://doi.org/10.1248/yakushi1947.96.8_952
Abstract
To examine anticholinergic activity of pyrrolidines analogous to 1,1-diethyl-3-diphenylmethylene-2-methylpyrrolidinium Br (Prifinium Br), cis- and trans-1,1,5-trimethyl-2-ethyl- and cis- and trans-1,1,2,4,5-pentamethyl-3-diphenylmethylene-pyrrolidinium iodides were synthesized. Their pharmacological activity was reported.This publication has 3 references indexed in Scilit:
- Anticholinergic agents. Synthesis of 4-diphenylmethylene-1,1,2,3-tetramethylpyrrolidinium iodide.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Anthicholinergic agents. Synthesis of 1,1,4-trimethyl- and 1,1,5-trimethyl-3-diphenylmethylenepyrrolidinium halides.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Cyclization towards Carbon-Carbon Double Bond. III. A New Synthesis of 1-Pyrroline Derivatives and a Synthesis of 1, 2-Dialkyl-3-diphenyl-methlenepyrrolidine Alkyl Halide, an Anti-acetylcholine SubstanceCHEMICAL & PHARMACEUTICAL BULLETIN, 1966