Effects of Physiological Infusion of Epinephrine in Normal Humans: Relationship between the Metabolic Response and β-Adrenergic Binding*
- 1 February 1980
- journal article
- retracted article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 50 (2) , 294-297
- https://doi.org/10.1210/jcem-50-2-294
Abstract
In normal humans, infusion of epinephrine for 4 h increased plasma epinephrine to 411 ± 38 pg/ml but had no significant effect on plasma insulin or glucagon levels. Epinephrine produced a prompt 45% rise in glucose output (P < 0.01) and a 120% rise in FFA (P < 0.001), both of which declined to basal levels by 60–90 min. Glucose clearance decreased by 25% (P < 0.005) and remained suppressed for 4 h. The binding of [125I]hydroxybenzylpindolol to lymphocytes was unchanged after epinephrine infusion. We conclude that in normal humans 1) physiological increments in epinephrine have a persistent effect in decreasing glucose clearance but only transiently increase hepatic glucose output and FFA levels and 2) this refractoriness of liver and adipose tissue to epinephrine occurs without a concomitant decrease in βS-adrenergic binding to lymphocytes.Keywords
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