Effect of restriction of placental growth on the concentrations of insulin, glucose and placental lactogen in the plasma of sheep

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Abstract
The effect of restricting placental growth on maternal glucose, insulin and placental lactogen was investigated in 16 ewes carrying singleton lambs. Uterine caruncles were removed from seven ewes (caruncle ewes) before pregnancy, resulting in reduced placental size and retarded intra-uterine fetal growth. The concentration of insulin in maternal plasma was similar in both control and caruncle ewes. The concentration of glucose was significantly higher in the caruncle than in the control ewes (3·26 ± 0·15 (s.e.m.) mmol/l, number of observations (n) = 9, vs 2·75 ± 0·1, n = 9, Pn = 7, vs 2·46± 0·11, n = 12, Pn = and 705±106 μg/l, n = 18, Pn = 9, and 621±96 μg/l, n = 18, Pn = 8, compared with 133±43 μg/min, n = 15, PJ. Endocr. (1985) 106, 7–11