Experimental megaileum
- 1 December 1995
- journal article
- Published by Springer Nature in Zeitschrift für Die Gesamte Experimentelle Medizin
- Vol. 195 (1) , 249-253
- https://doi.org/10.1007/bf02576795
Abstract
Typical megaileum occurred in young male Wistar rats three months after ileum myenteric plexus denervation. An average of 58.4% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in an 8 nm ring-shaped histological sectfrom the midportion of the treated segment. A morphometric study showed that the increased thickness of the megaileum wall was due to muscle hypertrophy and mucosal hyperplasia. The potential usefulness of this model of megaileum is emphasized.Keywords
This publication has 5 references indexed in Scilit:
- Abnormal progression of a liquid meal through the stomach and small intestine in patients with Chagas' diseaseDigestive Diseases and Sciences, 1993
- Megacolon in RatsDigestion, 1990
- Megaíleo chagásico: Descrição de um casoRevista do Instituto de Medicina Tropical de São Paulo, 1988
- Selective destruction of intestinal nervous elements by local application of benzalkonium solution in the ratCellular and Molecular Life Sciences, 1979
- Pathology of an East African megacolon.Gut, 1966