A MULTICENTRE STUDY OF THE EFFECT AND TOLERANCE OF OCUSERT‐P‐40

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Abstract
The suitability of treatment with Ocusert®‐P‐40, a lamellar system inserted in the eye and allowing the constant release of pilocarpine, was studied in a group of patients (age range 43–83 years) with wide‐angle glaucoma. Those patients completing a 3‐week trial were included in an 8 month follow‐up study in which the long‐term efficacy and tolerance of Ocusert® were studied.Treatment was discontinued in 13 of the 42 patients in the 3‐week trial owing to initial irritation and retention problems (n= 11) or unsatisfactory control of the intraocular pressure (I.O.P.) (n=2). Of the 29 patients entering the long‐term study, two were withdrawn because of tolerance problems and two as a result of unsatisfactory control of I.O.P. The 25 patients completing the study considered the Ocusert® system more convenient and less liable to produce troublesome side‐effects than their previous therapy. Ocusert® was best tolerated by the younger patients.

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