Cancer chromosomes in crisis
- 1 September 2004
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 36 (9) , 932-934
- https://doi.org/10.1038/ng0904-932
Abstract
The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.Keywords
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