Bucrylate Tissue Adhesive for Microvascular Anastomosis

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Abstract
Anastomosis of the divided abdominal aorta (0.8 to 1.8 mm in diameter) of 52 rats was accomplished either by continuous suture or by application of bucrylate (isobutyl-2-cyanoacrylate) following placement of three stay sutures. One of 24 (4%) anastomoses in the suture group failed, and five of 28 (18%) anastomoses in the tissue adhesive group failed. The remainder of the rats were killed at intervals of 1 to 42 days, and sections from the anastomoses in each group were examined histologically. Degeneration of the media and deposition of calcium was seen in the vessels in the bucrylate group. In addition, a more intense and prolonged foreign-body giant-cell response was noted in comparison to vessels in the suture group.