DIFFERENCES IN EXPERIMENTAL PANCREATIC CARCINOGENESIS INDUCED BY ORAL OR SUBCUTANEOUS ADMINISTRATION OF 2,2'-DIHYDROXYDI-NORMAL-PROPYLNITROSAMINE IN DUCT-LIGATED HAMSTERS
- 1 January 1981
- journal article
- research article
- Vol. 41 (11) , 4715-4719
Abstract
After ligation of the main pancreatic duct in the splenic lobe, Syrian golden hamsters were treated, p.o [orally] or s.c., for 15 wk with dihydroxydi-n-propylnitrosamine for induction of pancreatic duct carcinomas. The incidence, location and type of proliferative lesions distal and proximal to the ligature were recorded and compared to those of dihydroxydi-n-propylnitrosamine-treated hamsters without duct ligation. Proliferative duct lesions, including carcinomas, developed on either side of the ligation. While after s.c. administration the incidence was similar to that in nonligated animals, a markedly decreased incidence was found in p.o.-treated animals with duct ligation. The data suggest that blood stream might be a major access route of the carcinogen to the pancreatic duct cell. It is assumed that an unimpaired release of pancreatic juice in the duodenum is necessary for the enteral resorption of dihydroxydi-n-propylnitrosamine.This publication has 6 references indexed in Scilit:
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