Production of Interferon by Alveolar Macrophages

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Abstract
Acton, JeanD. (Bowman Gray School of Medicine, Winston-Salem, N.C.),and Quentin N. Myrvik. Production of interferon by alveolar macrophages. J. Bacteriol.91:2300–2304. 1966.—Rabbit alveolar macrophages inoculated with parainfluenza-3 virus in vitro produce a viral inhibitor which possesses the properties of interferon. The interferon is nondialyzable, is stable atpH 4, is not sedimented at 100,000 ×g, exhibits species specificity, and can passively protect other alveolar macrophages from infection with virulent rabbitpox virus. The possible significance of alveolar macrophage-produced interferon is discussed.