In Vitro Activity of Syn-2869, a Novel Triazole Agent, against Emerging and Less Common Mold Pathogens

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Abstract
The in vitro activity of Syn-2869 was compared with that of amphotericin B and itraconazole. MICs for 100 isolates of pathogenic molds belonging to 12 species were determined by a broth microdilution adaptation of the method recommended by the National Committee for Clinical Laboratory Standards. Syn-2869 and itraconazole showed comparable, good activity against the dematiaceous molds Cladophialophora bantiana , Cladophialophora carrionii , Exophiala dermatitidis , Fonsecaea pedrosoi , Phialophora parasitica , and Ramichloridium mackenziei . Neither of the azole agents was active against the hyaline molds Fusarium solani , Scedosporium prolificans , and Scopulariopsis brevicaulis , but both were more active than amphotericin B against Scedosporium apiospermum . The MICs of the three agents were comparable for the mucoraceous mold Absidia corymbifera , but Syn-2869 appeared to be the least active against the dimorphic mold Sporothrix schenckii . Our results suggest that Syn-2869 could be effective against a range of mold infections in humans.