LORMETAZEPAM - A BENZODIAZEPINE DERIVATIVE WITHOUT HANGOVER EFFECT - A DOUBLE-BLIND-STUDY WITH CHRONIC INSOMNIACS IN A GENERAL-PRACTICE SETTING

  • 1 January 1981
    • journal article
    • research article
    • Vol. 19  (1) , 11-19
Abstract
Lormetazepam, a new short-acting benzodiazepine, was tested multicentrally in 15 general practices. The subjects were 62 chronically sleep-disturbed patients. The first 7 days served as a placebo baseline week, the next 14 days were either lormetazepam or placebo in a randomized double-blind design and during the last week placebo was given again to measure rebound effects. Lormetazepam was an effective hypnotic that caused virtually no hangover the next morning. No rebound effects could be measured. Visual analog scales, among others, were used for the assessment of sleep characteristics.

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