Effects of Calmodulin Antagonists Cd2+ and Trifluoperazine on Mixed Lymphocyte Culture Cell‐Mediated Lysis and Antibody‐Dependent Cell Cytolysis

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Abstract
The effects of two substances with calmodulin-antagonistic properties, cadmium and trifluoperazine, were studied on mixed lymphocyte culture-cell mediated lysis (MLC-CML) and antibody-dependent cell cytolysis (ADCC). Both cadmium and trifluoperazine readily inhibited MLC-CMC, while ADCC was inhibited only to a small extent or not at all. Trifluoperazine almost completely inhibited phagocytosis in cells whose ability to lyse antibody-coated red blood cells was unimpaired. The results a striking difference in the extent in which calmodulin mediated processes take part in MLC-CML on the one hand and ADCC on the other. This indicates a profound dissimilarity in the mechanisms of these two types of cell-mediated lysis.