Serum Pepsinogen I as a Predictor of Stomach Cancer
- 1 October 1980
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 93 (4) , 537-540
- https://doi.org/10.7326/0003-4819-93-4-537
Abstract
Among 7498 Japanese men who were examined from 1967 to 1970, 48 were subsequently diagnosed with stomach cancer and had premorbid stored sera available for serum pepsinogen I analysis. The median interval between serum collection and diagnosis of cancer was 44.5 mo. (range, 3-103 mo.). A low pepsinogen I level was found in 15 of the 48 patients with stomach cancer and in only 6 (6.3%) of 96 matched control subjects (P < 0.001). All 15 patients with low pepsinogen I levels belonged to the subgroup of 38 who had the intestinal-mixed-other histologic types of gastric cancer. A low serum pepsinogen I level is a subclinical marker of increased risk for these histologic types of gastric cancer.Keywords
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